Fig. 3

Resected neuroblastoma histology, demonstrating A Low-power view of the tumour with nests of small blue primitive-appearing cells floating within an oedematous and fibrillary background, B Medium power view demonstrating a variety of tumour cells ranging from small- and primitive-appearing (neuroblasts, yellow arrow) to larger cells with moderate amounts of eosinophilic cytoplasm and large nuclei (ganglion cells, black arrow) against a neurofibrillary background, C Higher power view demonstrating morphology of tumour cells in different stages of maturation from neuroblasts (blue arrow) to ganglion cells (black arrow), D Nests of undifferentiated neuroblasts against a haemorrhagic background, and E Pseudo-Rosette formation: arrangement of tumour cells around a central area filled with neurofibrillary processes