Table 1 Cases of developing HBS after PTX
Author (Year) | Sex/Age | Presentation | Comorbidities | Diagnosis | Bone Radiography | Complication | Treatment of HBS |
|---|---|---|---|---|---|---|---|
Varma et al. (2014) [24] | F/36 | HyperCa & PTH crisis | N/A | P-HPT due to PC | Lytic lesions in the right femoral neck, right Sup. and Inf. pubic bones and left iliac wing | Osteitis fibrosa cystica | IV and oral Ca |
Neagoe et al. (2014) [25] | M/57 | Osteoarticular pains, muscular weakness, nausea & abdominal pains | Renal stones, Osteoporosis, HLP, IHD, Prostate adenoma | P-HPT due to PA | N/A | None | IV Ca-gluconate, Oral Alfacalcidol |
F/60 | Fatigue, muscular weakness, nausea, vomiting & dehydration | Hypothyroidism, Peptic disease | P-HPT due to PA | N/A | None | Oral Ca | |
Altun et al. (2015) [25] | F/20 | HyperP, HypoCa & PTH crisis | ESRD on HD, Anuria | HPT-II without PA | N/A | Prolonged HypoP | IV Ca, Oral CaCO3 & calcitriol |
F/32 | HypoCa & PTH crisis | CTIN secondary to NBSD, HD, Anuria | |||||
M/35 | PTH crisis | AA amyloidosis secondary to FMF, HD, Anuria | |||||
Ebina et al. (2015) [27] | M/16 | Hip & right forearm pain | None | P-HPT due to PA | Lytic fractured lesion in both femoral neck and radial shaft | Multiple brown tumors & secondary osteoporosis | IV Ca & Mg, Oral Ca & calcitriol |
Saif et al. (2015) [28] | F/15 | Recurrent vomiting & abdominal pains | None | P-HPT due to PA | Osteopenia and lytic areas in the left iliac bone, the femoral neck bilaterally, and the right pubic bone | HyperCa-induced pancreatitis | IV & oral Ca, Oral Alfacalcidol |
Rutledge et al. (2016) [29] | F/21 | Enlarging right-sided neck mass | None | P-HPT due to APA | No osseous abnormalities | None | IV Ca, Oral Alfacalcidol, Oral P & Mg |
Afshan et al. (2017) [30] | M/32 | Perioral numbness, tingling, diffuse paresthesia & weakness | ESRD on PD, HTN, GERD | N/A | N/A | Severe & recurring HypoCa | Changing oral CaCO3 to Ca-citrate with oral clcitriol |
Hendarto et al. (2017) [31] | F/18 | Generalized bone pain | None | P-HPT due to PA | Severe scoliosis, multiple old fractures, bone erosions and resorption of the phalanges | None | Parenteral & oral Ca |
Tai et al. (2018) [32] | F/56 | Frequent urination, generalized weakness & pain | HTN, HLP, DM | P-HPT due to PA | Triangular fibrocartilage complex chondrocalcinosis | Pseudogout | IV Ca & Mg, Colchicine, Naproxen |
Florakis et al. (2019) [33] | M/44 | Chronic arthralgia & myalgia | None | P-HPT due to APA | Diffuse osteopenia of hip-pelvis and lumbar spine | HPT-II due to vit D deficiency | Alfacalcidol, Ca, vit D and Mg |
Tai et al. (2019) [34] | M/74 | HyperP, HyperCa & PTH crisis | ESRD on HD, HTN | HPT-III due to PG & ectopic PG | N/A | None | IV Ca-chloride, Oral Ca-acetate and vit D |
Ahmed et al. (2020) [35] | F/35 | HypoCa & PTH crisis | SLE, on HD | HPT-II | N/A | None | IV Ca & vit D, Oral Ca & teriparatide |
Buisset et al. (2020) [36] | F/20 | HyperCa & PTH crisis | None | P-HPT due to PC | Diffuse bone demineralization | Osteitis fibrosa cystica & multiple brown tumors | Oral Ca & vit D |
Lenherr-Taube et al. (2020) [37] | F/13 | HyperCa & PTH crisis | Bilateral genu varum, Hip impingement | P-HPT due to PA | Lytic lesions throughout the skeleton and widening of the bilateral sacroiliac joints | None | IV Ca, Oral CaCO3 & calcitriol |
Raj et al. (2020) [38] | F/66 | HypoCa & PTH crisis & fatigue | Renal stones | P-HPT due to PA | N/A | HPT-II due to CKD | IV Ca-gluconate, Oral Ca, calcitriol & Ergocalciferol |
Alvarez et al. (2022) [39] | F/55 | Mechanical pain in the right shoulder & loss of strength | Osteoarthritis, HTN | P-HPT due to PA | Lytic lesions on the proximal humerus, sternum, acromion, sixth anterior left costal arch, iliac bones, left femoral head, and fracture of the Sup. vertebral disc | Acute and chronic pulmonary embolisms | IV Ca-gluconate, Oral calcitriol & Ca |
Landeta et al. (2022) [40] | M/56 | HyperP, HypoCa & PTH crisis | HTN, BPH | P-HPT due to PA | N/A | None | IV Ca-gluconate, Oral CaCO3 |
Vitale et al. (2022) [41] | M/12 | Nausea, HyperCa & PTH crisis | Obesity, Autism spectrum disorder | P-HPT due to PA | N/A | None | Oral Ca & calcitriol |
Zelano et al. (2022) [42] | M/56 | HypoCa, fatigue, abdominal pain, vomiting, dehydration & weight loss | None | P-HPT due to PC | Calcification in the cartilage around the joints, associated with synovitis in hands, wrists, elbows, knees, and ankles | Articular pain & pancreatic exocrine insufficiency | IV Ca, Oral calcitriol |
Martínez‑Loya et al. (2023) [43] | M/34 | Muscle weakness | Bilateral hip fractures | P-HPT due to PA | N/A | None | IV Ca, Oral calcitriol & CaCO3 |
Nievera et al. (2023) [44] | M/21 | Severe pain of both thighs & his legs give way | None | P-HPT due to PA | Displaced fractures of both upper femoral shafts | None | IV Ca-gluconate, Oral Ca |
Shah et al. (2023) [45] | M/64 | Inability to walk for nine days & bilateral knee pain radiating to shins | HTN, DM | P-HPT due to PA | N/A | None | Oral calcitriol & CaCO3 |
Liu et al. (2024) [46] | M/57 | Multiple pathological fractures, muscle atrophy & bone pain | None | P-HPT due to PC | Femoral neck fracture and muscle atrophy around the left hip, bilateral humeral shaft fractures | Numbness in perioral sites and fingertips | IV Ca-gluconate, Oral Vit D |
Papanikos et al. (2024) [47] | M/67 | HyperCa, nausea, drowsiness, & weakness | HTN, HLP, Hyperuricemia | P-HPT due to PA | N/A | None | IV Ca-gluconate, Oral Alfacalcidol |