Bone health in young adults with type 1 diabetes and progressive eGFR decline

Table 4 Relationship between tibia HRpQCT parameters and demographic and diabetes variables

HRpQCT parameters	Hemoglobin A1C			Diabetes duration			BMI			Vitamin D level
HRpQCT parameters	R²	β	p	R²	β	p	R²	β	p	R²	β	p
Tt.BMD (mgHA/cm³)	0.1	7.4	0.08	0.08	0.2	0.9	0.09	0.7	0.4	0.08	0.02	0.9
Tt. Ar (mm²)	0.3	5.0	0.7	0.3	-8.4	0.06	0.3	3.5	0.06	0.2	-0.2	0.7
Ct.BMD (mgHA/cm³)	0.3	1.7	0.6	0.3	1.8	0.2	0.3	0.4	0.6	0.3	-0.2	0.2
Ct.Ar (mm²)	0.35	3.2	0.07	0.3	-0.8	0.3	0.3	0.9	0.003*	0.3	-0.08	0.3
Ct.Th (mm)	0.1	0.04	0.07	0.1	1x10^-4	1.0	0.1	0.006	0.2	0.1	-8x10^-4	0.4
Ct.Pm (mm)	0.3	0.1	0.9	0.3	-0.6	0.05	0.3	0.3	0.03	0.3	-0.01	0.7
Ct.Po (%)	0.1	7x10^-4	0.2	0.1	-2x10^-4	0.4	0.1	-5x10^-6	1.0	0.1	2x10^-5	0.4
Ct.Po.Dm (mm)	0.1	4x10^-3	0.1	0.1	-4x10^-5	1.0	0.1	1x10^-4	0.8	0.1	-4x10^-5	0.7
Tb.BMD (mgHA/cm³)	0.3	4.4	0.05	0.3	-1.5	0.1	0.3	0.6	0.2	0.3	0.1	0.2
Tb.Ar (mm²)	0.2	2.0	0.9	0.2	-7.7	0.08	0.2	2.9	0.1	0.2	-0.08	0.8
Tb.N (1/mm)	0.08	0.008	0.6	0.1	-0.01	0.06	0.09	0.003	0.3	0.1	0.001	0.02
Tb.Sp (mm)	0.08	-0.008	0.3	0.09	0.005	0.1	0.08	-0.001	0.4	0.1	-8x10^-4	0.01*
Tb.Th (mm)	0.2	0.002	0.33	0.2	3x10^-4	0.6	0.2	3x10^-4	0.3	0.3	-9x10^-5	0.2

vBMD volumetric bone mineral density, Ctcortical, Th thickness, Tb trabecular, Sp separation, N Number, Ct. Pm cortical perimeter, Ct. Po cortical porosity, Ct.Po.Dm cortical porosity diameter
^*Significance at p \(\le\)0.01. linear regression analysis with adjustment of covariates of relationship between HbA1C, diabetes duration, body mass index, 25 hydroxy-vitamin D level, and tibia HRpQCT parameters. Adjusted R², beta coefficient and p values are reported

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