Table 1 Methodology
From: Metformin mitigates dementia risk among individuals with type 2 diabetes
Methodology Component | Details |
|---|---|
Database Search | PubMed, Embase, Google Scholar, Scopus |
Search Strategy | Formulated using keywords: "diabetes," "diabetes mellitus," "diabetes mellitus, Type 2," "metformin," "biguanides," "metformin benefits," "anti-diabetic medications," "memory," "cognition," "cognitive-impairment," "amnestic mild cognitive impairment," "Alzheimer's disease," "Parkinson's disease," and "dementia." |
Boolean Operators | ((dementia) OR (cognitive-impairment) OR (cognitive function) OR (neurodegenerative diseases)) AND ((metformin) OR (anti-diabetic drugs)) |
Additional Sources | Other texts from existing literature and related bibliographies |
Manual Search | Reviewed relevant articles cited within retrieved studies |
Inclusion Criteria | a) Results in English, b) Full text available, c) Specifically assessed dementia risk in patients with diabetes on metformin therapy |
Exclusion Criteria | a) Missing data, b) Not focusing on metformin use in type 2 diabetes mellitus, c) Studies on patients with significant neurological, psychiatric disease or cancer, d) Studies in vitro or animal models |
Study Scope | Randomised controlled trials, retrospective cohort studies, prospective observational studies, comparator studies, and case–control studies |
Excluded Types | Books, letters, editorials, conferences, commentaries |
Data Extraction | Evaluated study characteristics: Publication type, year, study design, study focus, sample size, number of positive and negative outcomes |